Gsk 4112, Selective Rev-Erbα Agonist, Each

Details

Gsk 4112 is a selective rev-erbα agonist (ec50 = 250 nm). Enhances recruitment of nuclear receptor co-repressor (ncor) peptide to rev-erbα; causes acute suppression of bmal1 gene transcription. Induces phase shifts in the circadian clock.