Ki 8751, Potent, Selective Vegfr-2 Inhibitor, Each

Details:

Ki 8751 is a potent, selective inhibitor of vegfr-2 tyrosine kinase (ic50 = 0.9 Nm). Displays some inhibitory activity towards c-kit, pdgfrα and fgfr-2 (ic50 values range from 40 to 170 nm) but is highly selective over other receptor tyrosine kinases (ic50 > 10000 nm for fgfr-2, egfr and hgfr). Inhibits vegf-stimulated proliferation of human umbilical vein endothelial cells (huvec) and inhibits tumor growth in vivo; antiangiogenic.