mm 102, Wdr5/Mll Interaction Inhibitor, Each

Details:

Mm 102 is a potent wdr5/mll interaction inhibitor (ic50 = 2.4 Nm). Inhibits mll1 methyltransferase activity and mll-1-induced hoxa9 and meis-1 gene expression in leukemia cells expressing the mll1-af9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring mll1 fusion proteins.