Mpep Hydrochloride, Potent Mglu5 Antagonist; Also Positive Allosteric Modulator Of Mglu4 Receptors, Each

Details:

Mpep hydrochloride is a potent and highly selective non-competitive antagonist at the mglu5 receptor subtype (ic50 = 36 nm) and a positive allosteric modulator at mglu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.