Mrs 2279, Selective, High Affinity P2y1 Antagonist, Each

Details:

Mrs 2279 is a selective, high affinity competitive antagonist of the p2y1 receptor (ki = 2.5 Nm; ic50 = 51.6 Nm). Fails to block nucleotide signaling at most other p2y receptors (p2y2, p2y4, p2y6, p2y11 and p2y12) and potently inhibits adp-induced aggregation of human blood platelets in vitro (pkb = 8.05).