Ns 398, Cyclooxygenase-2 (Cox-2) Inhibitor, Each

Details:

Ns 398 is a selective cyclooxygenase-2 inhibitor (ic50 values are 3.8 And > 100 μm for cox-2 and cox-1 respectively). Induces apoptosis in colorectal tumor cells and elevates cox-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.