S-Trityl-L-Cysteine, Potent, Selective Inhibitor Of Mitotic Kinesin Eg5, Each

Details:

S-trityl-l-cysteine is a potent, cell-permeable, selective inhibitor of mitotic kinesin eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal atpase activity (ic50 = 1 mm) and microtubule-activated atpase activity of eg5 (ic50 = 140 nm). Induces mitotic arrest in hela cells with an ic50 of 700 nm. Displays antitumor activity.