Sb 334867, Selective Non-Peptide Ox1 Antagonist, Each

Details:

Sb 334867 is a selective non-peptide orexin ox1 receptor antagonist. Pkb values are 7.2 And < 5 for inhibition of intracellular ca2 release in cho cells expressing human ox1 and ox2 receptors respectively. Blocks orexin-a induced grooming and feeding following systemic administration in vivo.