XRCC4, Rabbit, Polyclonal Antibody, Abnova, Rabbit polyclonal antibody raised against synthetic peptide of XRCC4, Each

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The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by nonhomologous end joining and the completion of V(D)J recombination events. The nonhomologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq